MEF2D — Myocyte enhancer factor 2D
MEF2D belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MEF2D's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Circadian Clock DNA/chromatin regulation | BHLHE40, CDK17, CPEB2, CRY1, IRF1, ITPRIP, NR1D2, PRKX +5 more | |
| Mucosal-associated invariant T cell | AP-1/MEF2 Activation T cell maturation | ADNP2, BHLHE40, CDK16, DBF4, ETF1, FOSL2, GADD45A, GPR35 +8 more |
About the gene
| Chromosome | 1: 156463727-156500779 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, Developmental protein, DNA-binding |
| Biological process | Apoptosis, Differentiation, Neurogenesis, Transcription, Transcription regulation |
Function
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.