TCR Early Activation
Gene co-expression module in Gamma-delta T cells
| Category | TCR Signaling |
|---|---|
| Genes | 24 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 24 genes have a known function matching the annotation |
Why this annotation
The hub genes define a classic TCR/NF-κB immediate early response: NFKBIA (IκBα, canonical NF-κB target and feedback inhibitor), ZFP36/ZFP36L2 (TIS11 family mRNA destabilizers induced by TCR), FOS (AP-1), BTG1/BTG2 (anti-proliferative IEGs induced by T cell activation), TNFAIP3 (A20, NF-κB feedback), NR4A2 (nuclear receptor induced by TCR signaling), DUSP1 (activation-induced phosphatase), TSC22D3 (GILZ, glucocorticoid/activation-regulated), CD69 (canonical early T cell activation marker), CXCR4 (upregulated post-activation). This is a tightly coherent strong module. The neighborhood context (M141 ER stress, M157 heat/IER stress) supports an activation-stress neighborhood, but this module is the clearest pure TCR activation IEG module.
Genes
BTG1, BTG2, CD69, CIRBP, CXCR4, DUSP1, EIF1, ETV3, FOS, H3-3B, LEPROTL1, MRPL10, NFKBIA, NR4A2, NSMCE3, PNRC1, PTGER4, SARAF, SBDS, TENT5C, TNFAIP3, TSC22D3, ZFP36, ZFP36L2
Most correlated modules
- ER Proteotoxic Stress · correlation 0.92
- Heat Stress Apoptotic · correlation 0.85
- Ubiquitin-p53 Regulation · correlation 0.84
- Late Activation Autophagy · correlation 0.84
- Pre-mRNA Splicing · correlation 0.81
- Anabolic Activation Response · correlation 0.81
- NF-κB Activation · correlation 0.81
- Stress Epigenetic Silencing · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.