TXNDC11 — Thioredoxin domain containing 11
TXNDC11 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TXNDC11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Circadian Clock DNA/chromatin regulation | BHLHE40, CDK17, CPEB2, CRY1, IRF1, ITPRIP, MEF2D, NR1D2 +5 more | |
| Macrophages | NF-κB AP-1 Signaling Inflammatory | ABL2, AGAP3, ARL8B, ATP1B3, ATP6V1H, B4GALT1, C5AR2, CDKN1A +21 more | View in SCUBA |
| Mucosal-associated invariant T cell | AP-1/MEF2 Activation T cell maturation | ADNP2, BHLHE40, CDK16, DBF4, ETF1, FOSL2, GADD45A, GPR35 +8 more |
About the gene
| Synonyms | EFP1 |
|---|---|
| Chromosome | 16: 11679083-11742857 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
Function
May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.