RNF139 — Ring finger protein 139
RNF139 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RNF139's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Plasma cell secretory B cell maturation | AARSD1, ATP1B3, BCAS2, CHMP1B, DNAJB9, ELL2, ETV3, IDI1 +9 more | View in SCUBA |
| CD4⁺ T cells | Immediate early activation TCR/AP1/NFKb pathway | ALG13, AREG, BCAS2, C9orf72, CXCR4, FAM222A, HIP1R, NR4A2 +18 more | View in SCUBA |
| Gamma-delta T cells | Ubiquitin-p53 Regulation Protein processing & ER | ATXN7, CCNL1, DCTN4, FNBP1, HERPUD2, MOB4, RBBP6, TP53BP2 +4 more | |
| Innate lymphoid cells | NR4A Activation Response activation | ALG13, ARL4A, BCAS2, CASP3, CHMP1B, CREM, DDX24, DLL1 +16 more | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB Activation Immune regulation | BCL3, FURIN, GTF3C1, IRAK1, IRS2, ISCA1, PITHD1, PRELID3B +3 more |
About the gene
| Synonyms | HRCA1, RCA1, TRC8 |
|---|---|
| Chromosome | 8: 124474880-124488618 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor, Transferase |
| Biological process | Ubl conjugation pathway |
Function
E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Involved in the sterol-accelerated degradation of HMGCR. This is achieved through binding of RNF139 to INSIG1 and/or INSIG2 at the ER membrane. In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.