SUZ12 — SUZ12 polycomb repressive complex 2 subunit
SUZ12 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SUZ12's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Epigenetic Chromatin Maintenance DNA/chromatin regulation | BAZ1B, DDX46, DNMT1, HNRNPAB, NASP, NOP56, SET, SMC1A +2 more | View in SCUBA |
| Endothelial | mRNA Splicing RNA processing & translation | DIAPH1, EIF4A3, FUBP1, GLRX5, HNRNPA2B1, HNRNPA3, HNRNPD, KHDRBS1 +8 more | View in SCUBA |
| Gamma-delta T cells | Pre-mRNA Splicing RNA processing & translation | AKAP7, ARID1A, CEP57, EIF4E, ENOSF1, GGNBP2, HERC5, HNRNPD +8 more | |
| Macrophages | Nuclear Pore Transport Housekeeping | AARS1, APH1A, ARF3, ATG3, CNOT7, CTDNEP1, DCAF7, GNAI2 +18 more | View in SCUBA |
About the gene
| Synonyms | CHET9, JJAZ1, KIAA0160 |
|---|---|
| Chromosome | 17: 31937007-32001038 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Disease related genes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.