T-bet Effector Differentiation
Gene co-expression module in Gamma-delta T cells
| Category | T cell maturation |
|---|---|
| Genes | 24 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 24 genes have a known function matching the annotation |
Why this annotation
The module has core coherence with strong anchor genes: TBX21 (T-bet, master transcription factor of Th1/effector T cell differentiation), GNAI2 (Gi2 alpha, chemotaxis and CXCR4/CCR signaling), FMNL1 (formin-like actin polymerization, critical for T cell migration and immune synapse), EFHD2 (EFhD2/Swiprosin-1, actin dynamics and B/T cell migration), SUN2 (LINC complex, nuclear migration, mechanosensing), CAPNS1 (calpain small subunit, cytoskeletal remodeling), LLGL2 (cell polarity), DGKZ (diacylglycerol kinase zeta, terminating DAG signaling downstream of TCR), ZBTB7A (transcription repressor, T cell differentiation), BCL7C (SWI/SNF chromatin remodeling, lymphocyte differentiation). TBX21 is the defining anchor for Th1/effector gd T cell state. The combination of migration machinery (GNAI2, FMNL1, EFHD2) and T-bet-driven transcriptional program identifies this as effector gd T cell differentiation with migratory capacity.
Genes
ABHD17A, BCL7C, CAPNS1, CHST12, DGKZ, EFHD2, FMNL1, GNAI2, GNB2, LLGL2, MFSD10, PIK3R2, RETREG2, RNF126, SELENOF, SPSB3, SRSF9, STUB1, SUN2, TBX21, TLE5, TRIR, TXNL4A, ZBTB7A
Most correlated modules
- TCR Vesicular Trafficking · correlation 0.91
- NKG2D Cytotoxic Activation · correlation 0.89
- Lymphocyte Homeostatic Regulation · correlation 0.88
- Immune Synapse Cytoskeleton · correlation 0.84
- Coinhibitory Checkpoint · correlation 0.83
- Effector Cell Migration · correlation 0.83
- TCR Proximal Signaling · correlation 0.82
- Protein Homeostasis Chaperones · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.