AHR-Cytokine Activation
Gene co-expression module in Glial cells
| Category | Activation |
|---|---|
| Genes | 10 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 10 genes have a known function matching the annotation |
Why this annotation
This is a weak coherence module with most hub genes showing weak membership. CDH19 (cadherin-19, glial/neural identity marker), IL6ST (gp130, IL-6 signal transducer), AHR (aryl hydrocarbon receptor, transcription factor activated by inflammatory/microbial metabolites), BHLHE40 (transcriptional repressor induced by hypoxia and cytokines), ITPR1 (IP3 receptor, calcium signaling), SYNE1 (nuclear envelope/cytoskeleton), HNRNPA3 (RNA binding), RBM39 (RNA splicing), UBE2B (ubiquitin conjugating enzyme), CAVIN1 (caveolae). The most biologically coherent cluster involves IL-6/cytokine signaling (IL6ST), AHR-mediated transcriptional response, and BHLHE40 as downstream effectors of inflammatory cytokine/metabolite sensing. AHR is activated by microbial tryptophan metabolites and inflammatory mediators in the gut, and together with IL6ST and BHLHE40 suggests a cytokine/AHR-mediated glial activation state. The weak coherence and mixed membership make this uncertain. Upregulation in UC inflammation supports an inflammatory activation label.
Genes
AHR, BHLHE40, CAVIN1, CDH19, HNRNPA3, IL6ST, ITPR1, RBM39, SYNE1, UBE2B
Most correlated modules
- ER Stress Response · correlation 0.84
- Proteostasis Stress Response · correlation 0.82
- ER Membrane Homeostasis · correlation 0.82
- Glial Neural Scaffolding · correlation 0.80
- TGF-beta ECM Remodeling · correlation 0.79
- Actin Cytoskeletal Organization · correlation 0.77
- Glial RNA Homeostasis · correlation 0.74
- Inflammatory Cytokine Signaling · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.