SCUBA

RBM39 — RNA binding motif protein 39

RBM39 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

RBM39's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsmRNA Splicing
RNA processing
AFF4, ARL6IP1, CALR, CCNL1, CLK1, DDX3X, DDX5, EIF4A2 +7 moreView in SCUBA
CD4⁺ T cellsPost-transcriptional regulation
RNA processing
BCL11B, CCDC14, CHD2, CHD6, CREBZF, DDX39B, DNASE1, EVI2B +21 moreView in SCUBA
CD8⁺ T cellsPre-mRNA Splicing
RNA processing & translation
BRD2, EIF3A, FUS, HNRNPU, HSPA9, NCL, PNN, RBM25 +5 moreView in SCUBA
Gamma-delta T cellsPre-mRNA Splicing
RNA processing & translation
BCLAF1, CENPC, CLK1, CNOT1, COG3, COPS2, DDX24, DDX3X +11 more
Glial cellsAHR-Cytokine Activation
Activation
AHR, BHLHE40, CAVIN1, CDH19, HNRNPA3, IL6ST, ITPR1, SYNE1 +1 moreView in SCUBA
Innate lymphoid cellsmRNA Stability & Splicing
RNA processing & translation
BUD31, EIF4G2, GNAI3, HSPA9, PABPC1, PABPC4, PAIP2, PAPOLA +6 moreView in SCUBA
MacrophagesmRNA Splicing Processing
Housekeeping
ACIN1, ARID3A, BOD1L1, CCNL2, CDK12, CLK4, DCP2, GPATCH2L +20 moreView in SCUBA
Mucosal-associated invariant T cellSplicing Regulation
RNA processing & translation
AREG, ARHGAP9, AZIN1, CCNH, CLK1, DDX24, DNAJB6, IL23R +9 more
Natural Killer cellsTGF-β Antagonism
Immune regulation
IFRD1, IRS2, MOB3A, SBDS, SMAD7, SRSF5, STK17B, ZBTB1 +1 moreView in SCUBA

About the gene

SynonymsCAPER, CAPERalpha, CC1.3, fSAP59, HCC1, RNPC2
Chromosome20: 35701347-35742312
Predicted locationIntracellular
Essential geneYes
Protein classEssential proteins, Plasma proteins, Predicted intracellular proteins
Molecular functionActivator, RNA-binding
Biological processmRNA processing, mRNA splicing, Transcription, Transcription regulation

Function

RNA-binding protein that acts as a pre-mRNA splicing factor. Acts by promoting exon inclusion via regulation of exon cassette splicing. Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.