JUNB — JunB proto-oncogene, AP-1 transcription factor subunit

JUNB belongs to a gene co-expression module in 16 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

JUNB's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	AP-1 Immediate Early BCR/AP1/NFKb pathway	BTG2, CD69, CD83, DUSP1, EIF1, FOS, FOSB, JUN +7 more	View in SCUBA
CD4⁺ T cells	Pol II Transcription Regulation DNA/chromatin regulation	ABHD5, BAIAP2, BRD2, CBX4, CDKN1C, CITED2, CKS2, EHD1 +28 more	View in SCUBA
CD8⁺ T cells	AP-1 Early Activation TCR Signaling	BTG2, CD69, EGR1, FOS, FOSB, IER2, LEPROTL1, LITAF +5 more	View in SCUBA
Endothelial	Shear Stress Response Stress	DNAJB1, DUSP1, EGR1, FOS, FOSB, HES1, HSP90AA1, HSPA1A +11 more	View in SCUBA
Gamma-delta T cells	AP-1 Immediate Early Response Stress	BRD2, CITED2, CSKMT, EGR1, EIF4A2, FRAT1, FRAT2, GADD45B +25 more
Glial cells	Immediate Early Gene Response Activation	DNAJB1, EGR1, FOS, FOSB, HES1, HSP90AA1, HSPA1A, HSPA1B +3 more	View in SCUBA
Goblet cells	Immediate Early Gene chromatin regulation & transcription	BTG2, DUSP1, EGR1, FOS, FOSB, IER2, JUN, JUND	View in SCUBA
Innate lymphoid cells	NF-κB Inflammatory Activation Inflammation	CDKN1A, CSRNP1, DUSP1, DUSP2, DUSP6, ELL2, EZR, FOS +26 more	View in SCUBA
Lymphatic endothelial	AP-1 Immediate Early Inflammation	DUSP1, EGR1, FOS, FOSB, HES1, HSPA8, IER2, JUN +7 more	View in SCUBA
Macrophages	Early response genes Inflammatory	ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4 +39 more	View in SCUBA
Monocytes	AP-1 Inflammatory Activation Inflammatory	COQ7, DUSP1, FOS, IER2, JUN, KCNE1, KLF6, NAIP +2 more	View in SCUBA
Mucosal-associated invariant T cell	AP-1 Immediate Early Stress	AMD1, BRD2, CITED2, CSKMT, FUS, GADD45B, GADD45G, H2AX +17 more
Natural Killer cells	AP-1 Immediate Early activation	BTG1, CITED2, CXCR4, DUSP1, DUSP2, FOS, JUN, KLF6 +1 more	View in SCUBA
Neutrophils	Immediate Early Response Stress	ADM, BTG2, DUSP1, EGR1, FOS, IER2, ZFP36
Pericytes	Immediate Early Gene Stress	DNAJB1, EGR1, FOS, FOSB, HSPA1A, HSPA1B, IER2, JUN +3 more	View in SCUBA
Smooth muscle cells	Immediate Early Response Stress	ATF3, BTG1, BTG2, CDKN1A, EGR1, FOS, GADD45B, HES1 +7 more	View in SCUBA

About the gene

Chromosome	19: 12791486-12793315
Predicted location	Intracellular
Essential gene	No
Protein class	Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Function

Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.