TSPAN3 — Tetraspanin 3
TSPAN3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TSPAN3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | TGF-beta/differentiation Intercellular communication | CDC42SE1, CEMIP2, ENC1, KLF3, LYST, SLC12A6, SMAD3, ST3GAL1 | View in SCUBA |
| Glial cells | ER-Mitochondria Housekeeping Mitochondrial & OxPhos | CNN3, COX6C, HMGN3, LDHB, NDUFB5, NDUFS8, PDIA3, TMBIM4 +2 more | View in SCUBA |
| Macrophages | Mixed Housekeeping Housekeeping | AP2M1, BAG1, CHMP4A, CISD2, COA6, CSNK2B, CYB5R3, DEGS1 +20 more | View in SCUBA |
| Monocytes | Biosynthetic Metabolic Activation Housekeeping | AHCY, EEF1B2, IMPDH2, NME1, NPM1, NUCKS1, PABPC4, PEBP1 +4 more | View in SCUBA |
About the gene
| Synonyms | TM4-A, TM4SF8, TSPAN-3 |
|---|---|
| Chromosome | 15: 77041404-77083984 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins, Transporters |
Function
Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.