TMBIM4 — Transmembrane BAX inhibitor motif containing 4
TMBIM4 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMBIM4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | MHC-II antigen presentation B cell maturation | ARID5A, CD52, CD74, CD79A, CTSS, CYBA, HLA-DPA1, HLA-DPB1 +9 more | View in SCUBA |
| CD4⁺ T cells | RNA & Chromatin Regulation RNA processing | ATRX, DCP2, DIP2A, HNRNPLL, KDM5B, NCOR1, OGDH, RIOK3 +7 more | View in SCUBA |
| Gamma-delta T cells | T Cell Homeostasis Housekeeping | ATP6V0E1, CALHM2, CNPY2, CSK, CSTB, DAD1, FERMT3, GTF2H5 +11 more | |
| Glial cells | ER-Mitochondria Housekeeping Mitochondrial & OxPhos | CNN3, COX6C, HMGN3, LDHB, NDUFB5, NDUFS8, PDIA3, TMBIM6 +2 more | View in SCUBA |
| Innate lymphoid cells | ILC-1 identity Differentiation | ABRACL, BLOC1S1, C19orf53, CD52, DAD1, FUCA2, GMFG, HMGN3 +20 more | View in SCUBA |
| Macrophages | ER Protein Processing Housekeeping | ACTR1A, ANXA7, ATP6AP1, ATP6AP2, ATP6V0B, ATP6V0E1, AUP1, BCAP31 +41 more | View in SCUBA |
| Mucosal-associated invariant T cell | ER & Mitochondrial Assembly Protein processing & ER | ANAPC11, ARRDC1, ATP5MC1, COA3, CSTB, DECR1, GSTK1, HINT2 +9 more |
About the gene
| Synonyms | CGI-119, GAAP, LFG4, S1R, ZPRO |
|---|---|
| Chromosome | 12: 66135846-66170027 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Apoptosis |
Function
Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.