SCUBA

SERP1 — Stress associated endoplasmic reticulum protein 1

SERP1 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SERP1's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsmRNA Splicing Factors
RNA processing
ARGLU1, CDKN2D, CLK1, ERO1B, FUS, GLS, HNRNPA2B1, ID1 +8 moreView in SCUBA
EndothelialInflammatory Stress Response
Stress
CRK, DLC1, GCLM, IFT20, KRAS, ODC1, SBDS, SERPINH1 +7 moreView in SCUBA
Gamma-delta T cellsAnabolic Activation Response
Housekeeping
ABHD5, ATF4, ATP6V0C, ATP6V1G1, BCL7B, BUD31, CALM2, CHRAC1 +26 more
Glial cellsER Stress Response
Stress
ANXA1, ARF4, CSNK1A1, HSPA5, KRT10, RAB32, RBM3, SET +4 moreView in SCUBA
Goblet cellsERAD ER Homeostasis
Protein processing & ER
ARF4, ATP2A2, C1orf122, DNAJB9, HERPUD1, JTB, LARP1B, PGM3 +1 moreView in SCUBA
Innate lymphoid cellsMitochondrial Housekeeping
Mitochondrial & OxPhos
COX7A2, COX7B, EEF1B2, EIF1AX, FTH1, HNRNPC, ID2, NAP1L1 +8 moreView in SCUBA
MacrophagesTranslation Initiation
Housekeeping
AKR1B1, CAMLG, CAPZB, EEF1D, EEF2, EID1, EIF3D, EIF3E +26 moreView in SCUBA
Mucosal-associated invariant T cellRNA Splicing m6A
RNA processing & translation
ARF1, ARF6, ATP5F1B, CIRBP, CORO7, EIF1B, EIF5A, EMD +15 more
Natural Killer cellsNK Cell Activation
activation
AKAP9, AKIRIN1, ALG13, DDX24, EIF1AX, ETF1, EZR, GNL3 +2 moreView in SCUBA

About the gene

SynonymsFLJ43424, RAMP4
Chromosome3: 150541998-150603228
Predicted locationIntracellular, Membrane
Essential geneNo
Protein classPredicted intracellular proteins, Predicted membrane proteins
Biological processProtein transport, Translocation, Transport, Unfolded protein response

Function

Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.