TST — Thiosulfate sulfurtransferase
TST belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TST's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Glutathione Detoxification Stress | EIF3K, GSTP1, HINT1, HMGA1, MGST1, MGST3, SLIRP, SNRPD2 +1 more | View in SCUBA |
| Hematopoietic progenitor cells | Erythroid Heme Synthesis Erythropoietic | BLVRB, HBQ1, HES6, MPC2, MPST, REXO2, SMIM10, TMEM14B +2 more |
About the gene
| Synonyms | RDS |
|---|---|
| Chromosome | 22: 37010859-37020183 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | RNA-binding, Transferase |
Function
Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.