TES — Testin LIM domain protein
TES belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TES's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Stress Response Stress | CRK, DLC1, GCLM, IFT20, KRAS, ODC1, SBDS, SERP1 +7 more | View in SCUBA |
| Fibroblasts | Caveolae Mechanosensing Migration & adhesion | CAVIN1, FNBP1, KLHL5, LDLRAD3, MAP3K20, PDLIM3, PHLDB2, PLEKHO1 +6 more | View in SCUBA |
| Gamma-delta T cells | Butyrophilin gd Activation TCR Signaling | ABI1, ADD3, ANXA6, ARHGAP1, ARHGAP25, ARHGAP30, ARHGEF2, BTN3A1 +16 more | |
| Goblet cells | Adhesion & Transport Cytoskeletal | AHCYL1, CHMP1B, DDX5, DYNC1H1, DYNC1LI2, EIF4G2, ITGB1, PTTG1IP +4 more | View in SCUBA |
| Innate lymphoid cells | NK Cytotoxic Regulation Cytotoxicity | ARHGAP30, BIN2, CAPN12, CHD9, CLK1, CTSC, CYB5B, DDX27 +29 more | View in SCUBA |
| Mucosal-associated invariant T cell | Lymphocyte Trafficking migration & adhesion | AASDHPPT, ANXA2, ARL14EP, ATP2A3, BIN1, BTN3A2, DGKZ, OSTC +8 more | |
| Smooth muscle cells | Collagen-Laminin Deposition ECM remodeling | COL5A1, COL5A2, COL6A3, LAMA4, LAMB1, NEGR1, PARVA, PCDH7 +4 more | View in SCUBA |
About the gene
| Synonyms | DKFZP586B2022, TESS-2, TESTIN |
|---|---|
| Chromosome | 7: 116210506-116258783 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.