TPRKB — TP53RK binding protein
TPRKB belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TPRKB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Transcriptional Elongation Control DNA/chromatin regulation | ANP32B, AP2M1, ARF5, AURKAIP1, CCDC124, CUEDC2, CYC1, DCTN3 +19 more | |
| Goblet cells | Chromatin Organization chromatin regulation & transcription | CBX3, HMGB1, HMGB3, HMGN1, HNRNPA2B1, PTMA, STMN1 | View in SCUBA |
| Macrophages | Spliceosomal snRNP Cell cycle | ANAPC11, BANF1, CCDC25, CCT8, ERH, FIBP, FKBP3, GLRX5 +30 more | View in SCUBA |
About the gene
| Synonyms | CGI-121, CGI121 |
|---|---|
| Chromosome | 2: 73729104-73737400 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins |
| Biological process | tRNA processing |
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.