Transcriptional Regulation
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 29 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 9 of 29 genes have a known function matching the annotation |
Why this annotation
Hub genes include INPP4A (phosphoinositide phosphatase, PI signaling), FRMD4A (FERM domain, polarity/adhesion), FCHO2 (FCH domain, clathrin-mediated endocytosis initiation), TCF7L2 (Wnt pathway transcription factor), SLC8A1 (sodium-calcium exchanger), RUNX2 (transcription factor), TET3 (DNA demethylase, epigenetic), MEF2A (transcription factor), TIAM1 (Rac1 GEF, migration), PRKCA (PKC alpha, signaling). The module is highly mixed with all-weak memberships. The most coherent sub-theme involves transcription factor activity (TCF7L2, RUNX2, MEF2A, TET3) combined with PI/calcium signaling (INPP4A, PRKCA, SLC8A1). This likely represents a loosely co-varying transcriptional regulatory program in macrophages.
Genes
ABCC4, ARHGAP12, ATP8B4, CBFA2T2, DLG1, FAM168A, FBXO42, FCHO2, FRMD4A, HERC1, INPP4A, KIF16B, MAP4K5, MEF2A, MFSD4B, PPP1R12B, PRKCA, RUNX2, SENP7, SFMBT2, SLC49A4, SLC8A1, SPATS2, TASOR2, TCF7L2, TET3, TIAM1, TNKS, UBR3
Most correlated modules
- DNA Damage Response · correlation 0.98
- Rho GTPase Signaling · correlation 0.98
- Ubiquitin Proteasome Regulation · correlation 0.97
- ER Stress Response · correlation 0.96
- Transcriptional Kinase Regulation · correlation 0.96
- Endosomal Rab Trafficking · correlation 0.96
- Rho GTPase Signaling · correlation 0.96
- Chromatin Epigenetic Regulation · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.