SCUBA

TAF7 — TATA-box binding protein associated factor 7

TAF7 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TAF7's module in each cell type

Cell typeModuleShares the module with
Innate lymphoid cellsmRNA Stability & Splicing
RNA processing & translation		BUD31, EIF4G2, GNAI3, HSPA9, PABPC1, PABPC4, PAIP2, PAPOLA +6 moreView in SCUBA
MacrophagesTranscriptional Elongation
Housekeeping		AKIRIN1, ATF4, ATXN2L, CCDC82, CDK9, CHMP1A, CLCN7, EIF5 +19 moreView in SCUBA
Mucosal-associated invariant T cellT cell Homeostasis
T cell maturation		APOL6, CD40LG, CNDP2, FAM118A, FCMR, GPR171, IFIH1, IL7R +19 more
Smooth muscle cellsSMC Phenotype Regulation
Development		ARHGAP42, BMPR2, CTXN1, EFR3A, FAM20B, HACD4, INPP5A, OSBPL1A +5 moreView in SCUBA

About the gene

SynonymsTAF2F, TAFII55
Chromosome5: 141259884-141320784
Predicted locationIntracellular
Essential geneYes
Protein classEssential proteins, Predicted intracellular proteins
Biological processTranscription, Transcription regulation

Function

The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2. Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.