NDUFAF3 — NADH:ubiquinone oxidoreductase complex assembly factor 3
NDUFAF3 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NDUFAF3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Mitochondrial OxPhos Mitochondrial & OxPhos | AP2M1, ATP5MF, ATP6V0B, AURKAIP1, BSG, CALM3, CLTB, CSNK2B +19 more | View in SCUBA |
| Innate lymphoid cells | Mitochondrial Lysosomal Housekeeping Mitochondrial & OxPhos | BTF3L4, C14orf119, EMC6, ETFA, IER3IP1, JTB, LAMP1, MRPL14 +7 more | View in SCUBA |
| Lymphatic endothelial | Mitochondrial OxPhos Complex Mitochondrial & OxPhos | ARL2, BLOC1S1, CHMP2A, CHURC1, COX5B, DCTN3, FIS1, MRPL43 +5 more | View in SCUBA |
| Monocytes | Mitochondrial Immune Regulation Mitochondrial & OxPhos | CALHM2, CORO1B, DNASE2, DOK2, SIGLEC10, SLC39A1, UCP2 | View in SCUBA |
| Smooth muscle cells | Proliferative Biosynthesis Housekeeping | ARF5, BUB3, CBX5, DCTN3, DUT, HMGN2, IDH2, KRTCAP2 +7 more | View in SCUBA |
About the gene
| Synonyms | 2P1, C3orf60, DKFZP564J0123, E3-3, MGC10527 |
|---|---|
| Chromosome | 3: 49020459-49023495 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins |
Function
Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.