Neutrophil Motility Cytoskeleton
Gene co-expression module in Neutrophils
| Category | Migration & adhesion |
|---|---|
| Genes | 18 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes GMFG (glia maturation factor gamma, actin dynamics), COTL1 (coactosin-like, actin-binding), CNN2 (calponin 2, actin/cytoskeleton), RHOG (Rho GTPase, cytoskeletal signaling), TUBA1A (alpha-tubulin), LIMD2 (LIM domain, focal adhesion/cytoskeletal), GNB2 (G-protein beta subunit, chemoattractant signaling), SELL (L-selectin, rolling/adhesion), SELPLG neighbor context, LILRA5/LILRA6 (activating immunoglobulin receptors), GPSM3 (G-protein signaling), LSP1 (lymphocyte-specific protein 1, F-actin binding), CDKN2D (CDK inhibitor, cell cycle exit). The dominant program is cytoskeletal reorganization and motility, with SELL and LILRA5/6 indicating a circulating/patrolling neutrophil state. LTB (lymphotoxin-B) and GLIPR1 are minor members. This cohesively represents a neutrophil migration/adhesion module.
Genes
CDKN2D, CNN2, COTL1, CST7, GLIPR1, GMFG, GNB2, GPSM3, JPT1, LILRA5, LILRA6, LIMD2, LSP1, LTB, RHOG, SELL, TUBA1A, ZNF467
Most correlated modules
- Neutrophil Differentiation · correlation 0.92
- Mature Neutrophil Identity · correlation 0.88
- S100 Alarmin Response · correlation 0.86
- Neutrophil Chemotaxis Receptors · correlation 0.81
- Inflammasome Signaling Regulation · correlation 0.75
- TLR Lipid Signaling · correlation 0.73
- Myeloid Identity · correlation 0.71
- Actin Cytoskeleton Dynamics · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.