Pentose Phosphate Pathway
Gene co-expression module in Neutrophils
| Category | Housekeeping |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
PGD (6-phosphogluconate dehydrogenase) and TKT (transketolase) are pentose phosphate pathway enzymes generating NADPH. GYG1 is glycogenin involved in glycogen synthesis. LBR (lamin B receptor) marks nuclear envelope maturation. CDA is cytidine deaminase expressed in mature neutrophils. SNX3 mediates endosomal sorting. CAP1 and ARPC2 are actin regulatory proteins. HMGB2 is a chromatin protein. ANXA3 is a neutrophil granule-associated annexin. This module reflects housekeeping metabolic and biosynthetic programs in mature neutrophils, including pentose phosphate pathway activity for NADPH production and glycogen metabolism.
Genes
ANXA3, ARPC2, CAP1, CDA, GYG1, HMGB2, LBR, PGD, SNX3, TKT
Most correlated modules
- NET Priming State · correlation 0.88
- Degranulation Trafficking · correlation 0.83
- Specific Granule Release · correlation 0.80
- Neutrophil Differentiation · correlation 0.77
- Actin Cytoskeleton Dynamics · correlation 0.77
- Apoptotic Neutrophil Program · correlation 0.75
- Neutrophil Differentiation · correlation 0.74
- Granulopoiesis Program · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.