ABHD17A — Abhydrolase domain containing 17A, depalmitoylase
ABHD17A belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ABHD17A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR Complex Activation TCR/AP1/NFKb pathway | ACTR3, C1GALT1, CD2, CD3D, CD3E, CD3G, CD81, CERK +14 more | View in SCUBA |
| Gamma-delta T cells | T-bet Effector Differentiation T cell maturation | BCL7C, CAPNS1, CHST12, DGKZ, EFHD2, FMNL1, GNAI2, GNB2 +15 more | |
| Pericytes | Vascular Junction Adhesion Migration & adhesion | CCDC85B, CDC37, ESAM, FYN, HECW2, PREX1, SELENON, SLC44A2 +2 more | View in SCUBA |
About the gene
| Synonyms | C19orf27, FAM108A1, MGC5244 |
|---|---|
| Chromosome | 19: 1876810-1885496 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Transporters |
| Molecular function | Hydrolase |
Function
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS. Has depalmitoylating activity towards DLG4/PSD95. May have depalmitoylating activity towards MAP6 (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.