SOS1 — SOS Ras/Rac guanine nucleotide exchange factor 1
SOS1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SOS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR signaling TCR/AP1/NFKb pathway | ACVR1C, ADA2, ANK3, CAMK4, CHD7, GCLM, GNAO1, MPP7 +15 more | View in SCUBA |
| Gamma-delta T cells | Ubiquitin Protein Quality Protein processing & ER | CHMP7, CLCN3, EDEM3, GART, GOPC, HERC4, KRIT1, LRIF1 +13 more | |
| Mucosal-associated invariant T cell | Chromatin Remodeling DNA/chromatin regulation | ANK3, ARHGAP15, ARL15, BCAS3, CAMKMT, CCDC91, DPYD, EDA +13 more | |
| Pericytes | RAS-Chromatin Signaling Housekeeping | CD2AP, CNOT6L, EFCAB14, SKAP2, SMARCA2, TMTC1, WNK1 | View in SCUBA |
About the gene
| Synonyms | GF1, GINGF, HGF |
|---|---|
| Chromosome | 2: 38962206-39124345 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.