TMTC1 — Transmembrane O-mannosyltransferase targeting cadherins 1
TMTC1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMTC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | EC Quiescence Identity Endothelial cell development | ABCC4, ARHGAP5, C1orf115, ENPP4, FAM107A, GIT2, IFNAR2, LRRFIP1 +8 more | View in SCUBA |
| Lymphatic endothelial | Hypoxia Response Stress | CNTNAP3B, ENOSF1, FBN1, FKBP5, FOXP2, HIF3A, HMCN1, KAT2B +11 more | View in SCUBA |
| Pericytes | RAS-Chromatin Signaling Housekeeping | CD2AP, CNOT6L, EFCAB14, SKAP2, SMARCA2, SOS1, WNK1 | View in SCUBA |
| Smooth muscle cells | Calcium Handling Contractility | ASAP2, DDX24, MYCBP2, NBDY, PDE1A, RBM24, RNF180, RRAS +3 more | View in SCUBA |
About the gene
| Synonyms | ARG99, FLJ31400, FLJ41625, OLF |
|---|---|
| Chromosome | 12: 29500840-29784759 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted membrane proteins |
| Molecular function | Transferase |
Function
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl- transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O- mannosyl-transferase on other proteins such as PDIA3
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.