SMARCA2 — SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SMARCA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Cytoskeletal Scaffolding Cytoskeletal | ADD1, AGPAT1, ANO6, ARL6IP5, CDC42BPA, CHURC1, DOCK1, ERC1 +6 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Remodeling Signaling DNA/chromatin regulation | AKAP13, BPTF, CARNMT1, CCDC6, CFLAR, CLASP1, CLASP2, DOCK10 +23 more | |
| Innate lymphoid cells | ILC3 identity Differentiation | ABCC1, BCL6, CCND3, CELF2, CHKB, DNAAF2, ENSG00000285976, EREG +31 more | View in SCUBA |
| Lymphatic endothelial | Actomyosin Contractility Cytoskeletal | AFAP1L1, C1orf21, COBLL1, EEA1, GNB1, MAP4, OSBPL8, PPP1R12A +6 more | View in SCUBA |
| Macrophages | Myeloid Differentiation Identity Developmental | ADCK2, ALOX5, ATP2C1, CCDC6, CDK6, CMTM7, DEF6, EEF2K +21 more | View in SCUBA |
| Mucosal-associated invariant T cell | STAT4 T cell Identity T cell maturation | ATF7IP, CAMK4, CBLB, CD96, CELF2, DENND4A, IKZF1, JMJD1C +7 more | |
| Pericytes | RAS-Chromatin Signaling Housekeeping | CD2AP, CNOT6L, EFCAB14, SKAP2, SOS1, TMTC1, WNK1 | View in SCUBA |
About the gene
| Synonyms | BAF190, BRM, hBRM, hSNF2a, SNF2, SNF2L2, SNF2LA, Sth1p, SWI2 |
|---|---|
| Chromosome | 9: 1980290-2193624 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Activator, DNA-binding, Hydrolase |
| Biological process | Neurogenesis, Transcription, Transcription regulation |
Function
ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF). The npBAF complex is essential for the self- renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.