Smooth Muscle Contractile
Gene co-expression module in Pericytes
| Category | Cytoskeletal |
|---|---|
| Genes | 11 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 11 genes have a known function matching the annotation |
Why this annotation
ACTA2 (alpha-smooth muscle actin), TAGLN (transgelin/SM22), TPM1, TPM2 (tropomyosins), MYL9 (myosin light chain 9), MYLK (myosin light chain kinase), FLNA (filamin A), PPP1R14A (CPI-17, myosin phosphatase inhibitor), NEXN (nexilin, actin-binding), and CSRP1 (cysteine-rich protein 1, smooth muscle LIM) constitute the canonical smooth muscle/pericyte contractile apparatus. S100A4 is also associated with smooth muscle and myofibroblast states. This is the core pericyte contractile identity module.
Genes
ACTA2, CSRP1, FLNA, MYL9, MYLK, NEXN, PPP1R14A, S100A4, TAGLN, TPM1, TPM2
Most correlated modules
- Myosin Phosphatase Regulation · correlation 0.84
- Pericyte ECM Production · correlation 0.83
- Focal Adhesion Cytoskeleton · correlation 0.77
- Quiescent Pericyte State · correlation 0.75
- Complement Regulatory Pericyte · correlation 0.74
- Inflammatory ECM Remodeling · correlation 0.66
- Pericyte Vascular Tone · correlation 0.65
- Pericyte Identity Differentiation · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.