NR4A1 — Nuclear receptor subfamily 4 group A member 1
NR4A1 belongs to a gene co-expression module in 14 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NR4A1's module in each cell type
About the gene
| Synonyms | GFRP1, HMR, N10, NAK-1, NGFIB, NUR77, TR3 |
|---|---|
| Chromosome | 12: 52022832-52059507 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Nuclear receptors, Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding, Receptor |
| Biological process | Inflammatory response, Transcription, Transcription regulation |
Function
Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3'. Binds 9-cis-retinoic acid outside of its ligand- binding (NR LBD) domain. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter. May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity). In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.