Inflammasome Activation
Gene co-expression module in Innate lymphoid cells
| Category | Inflammation |
|---|---|
| Genes | 28 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
The top hub genes include RIPK2 (receptor-interacting kinase 2, essential for NOD1/NOD2 signaling), NLRP3 (inflammasome sensor), IFNGR1 (IFN-γ receptor), and ISG20 (interferon-stimulated exonuclease). ZFP36L2 is a post-transcriptional regulator that dampens inflammatory mRNA stability. FYN and PIK3IP1 modulate TCR/NK receptor signaling. Together these genes define an innate immune sensing and inflammasome activation program. The module is weak in coherence and shows mixed subset enrichment (res_ILC3, circ_ILC3, ILC1), suggesting a shared innate activation state across ILC subsets. Neighbor context (M8, M84 being ILC3-contaminated) suggests some ILC3 signal bleeds in, but the NLRP3/RIPK2/IFNGR1 core is functionally coherent as inflammasome/innate immune activation.
Genes
ANKRD28, AP3D1, ARHGEF7, CCNH, CD55, CDC42SE1, CHD7, CHKA, CRYBG1, CYGB, FYN, HIPK2, HNRNPUL1, IFNGR1, IKZF1, ISG20, IZUMO4, LDLRAD3, MPV17L, NLRP3, PIK3IP1, PIM2, RIPK2, SLC31A2, SMIM3, SYTL3, TLE1, ZFP36L2
Most correlated modules
- ILC3 identity · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.