PPP2R2A — Protein phosphatase 2 regulatory subunit Balpha
PPP2R2A belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPP2R2A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | IL6-STAT3 Signaling Intercellular communication | ARID5A, ARL6IP1, AZIN1, CCDC66, CDC40, CEMIP2, CHD1, CSNK1D +13 more | View in SCUBA |
| Gamma-delta T cells | Autophagy Stress Response Stress | AKIRIN1, BRD9, CDKN2AIP, DHX36, DNAJB2, FOXO3, MLXIP, ODF2L +11 more | |
| Innate lymphoid cells | Golgi RNA Processing RNA processing & translation | ANKRD12, ATM, DDX17, GCC2, GOLGA4, LUC7L3, MIER1, MLEC +11 more | View in SCUBA |
| Macrophages | Microtubule Organization Cytoskeletal | CAMSAP2, DESI2, FAF2, HERPUD2, KCMF1, LSM14A, MAPK6, NRDC +14 more | View in SCUBA |
About the gene
| Synonyms | B55A, B55alpha, PR52A, PR55A, PR55alpha |
|---|---|
| Chromosome | 8: 26291508-26372680 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Substrate-recognition subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. Involved in chromosome clustering during late mitosis by mediating dephosphorylation of MKI67 (By similarity). Essential for serine/threonine-protein phosphatase 2A- mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.