ST3GAL1 — ST3 beta-galactoside alpha-2,3-sialyltransferase 1
ST3GAL1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ST3GAL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | TGF-beta/differentiation Intercellular communication | CDC42SE1, CEMIP2, ENC1, KLF3, LYST, SLC12A6, SMAD3, TSPAN3 | View in SCUBA |
| CD4⁺ T cells | Transcriptional regulation DNA/chromatin regulation | CCNH, CWC25, DYNLL2, EIF2A, GOLGB1, IVNS1ABP, JMJD1C, KRR1 +8 more | View in SCUBA |
| Fibroblasts | IL-1 Receptor Signaling Inflammatory | CHIC2, GNAI1, IL1R1, MMD, PDLIM1, PRR16, SMIM3, TUSC3 | View in SCUBA |
| Gamma-delta T cells | TCR Inhibitory Signaling Exhaustion | AFF4, CBLB, CCNH, CCNT1, CHD2, CRYBG1, FYN, ISG20 +9 more | |
| Hematopoietic progenitor cells | HOX HSC Program Stemness | ADGRE2, AFF1, ARHGAP25, HOXA3, HOXA6, HOXA9, JAML, LPIN1 +3 more | |
| Macrophages | NF-κB AP-1 Signaling Inflammatory | ABL2, AGAP3, ARL8B, ATP1B3, ATP6V1H, B4GALT1, C5AR2, CDKN1A +21 more | View in SCUBA |
About the gene
| Synonyms | SIAT4A, SIATFL, ST3GalA.1, ST3O |
|---|---|
| Chromosome | 8: 133454848-133571940 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Glycosyltransferase, Transferase |
| Biological process | Lipid metabolism |
Function
A beta-galactoside alpha2->3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids. Catalyzes the transfer of sialic acid (N-acetyl- neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage. Adds sialic acid to the core 1 O-glycan, Galbeta-(1->3)-GalNAc-O- Ser/Thr, which is a major structure of mucin-type O-glycans. As part of a homeostatic mechanism that regulates CD8-positive T cell numbers, sialylates core 1 O-glycans of T cell glycoproteins, SPN/CD43 and PTPRC/CD45. Prevents premature apoptosis of thymic CD8-positive T cells prior to peripheral emigration, whereas in the secondary lymphoid organs controls the survival of CD8-positive memory T cells generated following a successful immune response (By similarity). Transfers sialic acid to asialofetuin, presumably onto Galbeta-(1->3)-GalNAc-O- Ser (By similarity). Sialylates GM1a, GA1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.