ALG13 — ALG13 UDP-N-acetylglucosaminyltransferase subunit
ALG13 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ALG13's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Hypoxia/metabolic stress Stress | ARL4A, C9orf72, HIP1R, PDE4B, SC5D, SLC2A3, TENT5C, VPS37B +2 more | View in SCUBA |
| CD4⁺ T cells | Immediate early activation TCR/AP1/NFKb pathway | AREG, BCAS2, C9orf72, CXCR4, FAM222A, HIP1R, NR4A2, PABPC1 +18 more | View in SCUBA |
| Innate lymphoid cells | NR4A Activation Response activation | ARL4A, BCAS2, CASP3, CHMP1B, CREM, DDX24, DLL1, DNAJB9 +16 more | View in SCUBA |
| Natural Killer cells | NK Cell Activation activation | AKAP9, AKIRIN1, DDX24, EIF1AX, ETF1, EZR, GNL3, PPP1CB +2 more | View in SCUBA |
About the gene
| Synonyms | CDG1S, CXorf45, FLJ23018, GLT28D1, MDS031, TDRD13, YGL047W |
|---|---|
| Chromosome | X: 111665811-111760649 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Glycosyltransferase, Hydrolase, Multifunctional enzyme, Protease, Thiol protease, Transferase |
| Biological process | Ubl conjugation pathway |
Function
Catalytic subunit of the UDP-N-acetylglucosamine transferase complex that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. On the cytoplasmic face of the endoplasmic reticulum, the dimeric ALG13/ALG14 complex catalyzes the second step of dolichol pyrophosphate biosynthesis, transferring a beta1,4-linked N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to GlcNAc-pyrophosphatedolichol (Gn-PDol) to produce N,N'-diacetylchitobiosyl diphosphodolichol. N,N'- diacetylchitobiosyl diphosphodolichol is a substrate for ALG1, the following enzyme in the biosynthetic pathway. Catalytic subunit of the UDP-N-acetylglucosamine transferase complex that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. On the cytoplasmic face of the endoplasmic reticulum, the dimeric ALG13/ALG14 complex catalyzes the second step of dolichol pyrophosphate biosynthesis, transferring a beta1,4-linked N- acetylglucosamine (GlcNAc) from UDP-GlcNAc to GlcNAc- pyrophosphatedolichol (Gn-PDol) to produce N,N'-diacetylchitobiosyl diphosphodolichol. N,N'-diacetylchitobiosyl diphosphodolichol is a substrate for ALG1, the following enzyme in the biosynthetic pathway. No glycosyltransferase or deubiquitinase activity is detected for this potential multifunctional enzyme
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.