LYPLA2 — Lysophospholipase 2
LYPLA2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LYPLA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Mitoribosome Small Subunit Mitochondrial & OxPhos | ACADM, C14orf119, CHCHD1, COA3, COA4, COMMD8, GALK1, GEMIN6 +24 more | |
| Mucosal-associated invariant T cell | Mitochondrial OxPhos Mitochondrial & OxPhos | ATP5MF, H2AZ1, H4C3, INO80E, NDUFA3, NDUFB1, SEM1, SGSM3 +3 more |
About the gene
| Synonyms | APT-2 |
|---|---|
| Chromosome | 1: 23791145-23795539 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Fatty acid metabolism, Lipid metabolism |
Function
Acts as an acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GSDMD, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6. Has lysophospholipase activity. Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha- glycerol ester (PGF2-alpha-G). Hydrolyzes 1- arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.