DBF4 — DBF4 zinc finger
DBF4 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DBF4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | mRNA Processing RNA processing | ABI1, AGFG1, CCND3, CD164, CHMP2B, GHITM, HNRNPL, LSM1 +9 more | View in SCUBA |
| Gamma-delta T cells | Heat Stress Apoptotic Stress | AMD1, DNAJB9, DUSP2, IER5, NFKBIB, NINJ1, PHLDA1, PMAIP1 +5 more | |
| Mucosal-associated invariant T cell | AP-1/MEF2 Activation T cell maturation | ADNP2, BHLHE40, CDK16, ETF1, FOSL2, GADD45A, GPR35, GSPT1 +8 more |
About the gene
| Synonyms | ASK, chif, DBF4A, ZDBF1 |
|---|---|
| Chromosome | 7: 87876216-87909553 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, DNA replication |
Function
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7- DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.