MZB1 — Marginal zone B and B1 cell specific protein
MZB1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MZB1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Immature T Cell T cell maturation | A1BG, ACP5, CD38, CD7, ID3, ITM2C, NCF1, NUDT14 +7 more | |
| Hematopoietic progenitor cells | Quiescent HSC State Stemness | ARHGEF17, BAALC, BIN1, CD52, GNAI1, HOPX, RBPMS, SPINK2 |
About the gene
| Synonyms | HSPC190, MEDA-7, MGC29506, PACAP, pERp1 |
|---|---|
| Chromosome | 5: 139387467-139390081 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins |
| Biological process | Apoptosis |
Function
Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B- cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation. Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.