PDHA1 — Pyruvate dehydrogenase E1 subunit alpha 1
PDHA1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PDHA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | Pyruvate Metabolism Metabolism | ABCB1, ADI1, ARID1B, ATF7IP2, CFAP298, EIF2AK2, HNRNPH3, MINDY2 +10 more | View in SCUBA |
| Macrophages | Ribosome Biogenesis Housekeeping | ABCE1, BCCIP, CLPX, COX20, DDX18, DUS1L, EIF3B, IDH3A +17 more | View in SCUBA |
About the gene
| Synonyms | E1alpha, PDHA |
|---|---|
| Chromosome | X: 19343893-19361718 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Citric acid cycle related proteins, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Carbohydrate metabolism, Glucose metabolism, Tricarboxylic acid cycle |
Function
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.