ER Stress Response
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Protein processing & ER |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
This module has moderate coherence with several weak-membership genes. Hub genes: TMBIM6 (anti-apoptotic/ER calcium channel, Bax inhibitor), HSP90B1 (GRP94, ER chaperone/heat shock protein), LENG8 (leukocyte receptor complex), ACADVL (very long chain acyl-CoA dehydrogenase, fatty acid oxidation), PIM1 (pro-survival kinase, downstream of cytokine signaling), SON (splicing factor), TNFSF14 (LIGHT, TNF superfamily ligand), GYG1 (glycogenin, glycogen synthesis), PLEKHF1 (apoptosis-related), MAP4K1 (HPK1, T cell signaling kinase), RGS3 (G protein signaling regulator), APOL3 (apolipoprotein L), HLA-F (non-classical MHC-I). The combination of ER stress chaperone (HSP90B1/GRP94), anti-apoptotic (TMBIM6), PIM1 (cytokine-responsive survival kinase), TNFSF14, and HLA-F suggests a program related to ER stress response and cell survival signaling. TNFSF14 and HLA-F add an immune activation/inflammation flavor. The module likely reflects a mixed ER stress + immune activation survival program.
Genes
ACADVL, APOL3, GYG1, HLA-F, HSP90B1, LENG8, MAP4K1, PIM1, PLEKHF1, RGS3, SON, TMBIM6, TNFSF14
Most correlated modules
- ER Protein Glycosylation · correlation 0.86
- Apoptosis Regulation · correlation 0.82
- Cellular Housekeeping · correlation 0.81
- Cellular Housekeeping · correlation 0.79
- MAIT Tissue Residence · correlation 0.79
- Chromatin Remodeling · correlation 0.78
- Oxidative Stress Response · correlation 0.78
- Actin Cytoskeletal Remodeling · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.