MAP4K1 — Mitogen-activated protein kinase kinase kinase kinase 1
MAP4K1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MAP4K1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Rho-GTPase Migration migration & adhesion | ARHGAP18, ARHGEF7, FNBP1, HELZ, LPXN, MIS18BP1, PREX1, RORA +4 more | View in SCUBA |
| CD8⁺ T cells | Gut Tissue Residency Gut residence | ALOX5AP, C4orf3, CAPN2, CD164, CD3D, CD7, CD99, CLIC3 +9 more | View in SCUBA |
| Gamma-delta T cells | Metabolic-Translational Coupling RNA processing & translation | APOL6, ARCN1, ARGLU1, DCAF12, DDX23, EIF2S1, EIF4G1, FHOD1 +20 more | |
| Mucosal-associated invariant T cell | ER Stress Response Protein processing & ER | ACADVL, APOL3, GYG1, HLA-F, HSP90B1, LENG8, PIM1, PLEKHF1 +4 more |
About the gene
| Synonyms | HPK1 |
|---|---|
| Chromosome | 19: 38587641-38618882 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Function
Serine/threonine-protein kinase, which plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway. May play a role in hematopoietic lineage decisions and growth regulation. Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.