SPP1 — Secreted phosphoprotein 1
SPP1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | SPP1 Inflammatory Activation Inflammation | ADAM15, ATG4A, C1orf54, C7orf50, C9orf40, CPXM2, EBF3, EIF2AK4 +9 more | View in SCUBA |
| Glial cells | Myelinating Schwann Cell Myelination | ALDH1A1, ARHGAP15, CXCL12, FCGR2B, MPZ, MXRA8, NTM, PRNP +1 more | View in SCUBA |
| Macrophages | SPP1 Tissue Remodeling ECM remodeling | BST1, CD52, CHI3L1, CHIT1, CSF1, FBP1, FGR, FN1 +19 more | View in SCUBA |
| Monocytes | SPP1+ Inflammatory Macrophage Inflammatory | DOCK4, DUSP4, FLT1, GPR137B, IL7R, INHBA, MMP14, NECTIN2 +6 more | View in SCUBA |
About the gene
| Synonyms | BNSP, BSPI, ETA-1, OPN |
|---|---|
| Chromosome | 4: 87975667-87983532 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted secreted proteins |
| Molecular function | Cytokine |
| Biological process | Biomineralization, Cell adhesion |
Function
Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.