TNRC6A — Trinucleotide repeat containing adaptor 6A
TNRC6A belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TNRC6A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Post-transcriptional Regulation Housekeeping | AKAP10, ATF7IP, ATRN, ATXN2, BAZ2B, BLTP1, BRWD1, CELF2 +34 more | View in SCUBA |
| Mucosal-associated invariant T cell | Transcriptional Repression Immune regulation | ANKRD11, CMIP, MXI1, NR3C1, PELI2, PROSER1, RB1CC1, RCOR1 +7 more |
About the gene
| Synonyms | CAGH26, GW182, KIAA1460, TNRC6 |
|---|---|
| Chromosome | 16: 24610209-24827632 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | RNA-binding |
| Biological process | Host-virus interaction, RNA-mediated gene silencing, Translation regulation |
Function
Plays a role in RNA-mediated gene silencing by both micro- RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA- dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.