B cell activation
Gene co-expression module in CD19⁺ B cells
| Category | BCR/AP1/NFKb pathway |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include CD86 (B cell activation/costimulation), SYK (BCR signaling), FAS (activation-induced apoptosis), PLEK, BCAR3, RAPGEF1. This is an activated B-cell signaling/costimulation module, closely related to M18 (both activated B cell programs, both inflammation-up/remission-down). SOX5 and TFEB add transcriptional regulation. Consistent activated effector/atypical memory B-cell state.
Genes
ADGRG5, BCAR3, CD86, CLIP2, CNOT2, CTSH, FAS, GABARAPL2, GPR137B, LIMK1, PEA15, PLEK, RAPGEF1, SOX5, SYK, TFEB
Most correlated modules
- BCR Ras signaling · correlation 0.88
- ER/vesicle trafficking · correlation 0.87
- B-cell activation · correlation 0.81
- Atypical memory B cell · correlation 0.81
- Activated B cell · correlation 0.78
- Actin cytoskeleton remodeling · correlation 0.77
- Tissue-resident memory B · correlation 0.74
- Actin Cytoskeleton · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.