Oxidative/ER stress
Gene co-expression module in CD19⁺ B cells
| Category | Stress |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes MAFG, HIC1, GZF1, FOSL2 are stress-responsive transcription factors. The module includes ER/oxidative stress genes (SDF2, ATP6V0D1, FAM210A), AP1 member FOSL2, GEM (immediate-early GTPase), and plasma cell/activation markers SLAMF7, PDCD1. MAFG with NFE2L2-like oxidative stress signaling plus ER stress chaperone SDF2 suggests an integrated stress/oxidative response program. Strong coherence, low expression. The presence of FOSL2/GEM links it to the neighboring AP1/NFKB modules but the dominant theme is stress-responsive transcription.
Genes
ASAH1, ATP6V0D1, B4GALT1, FAM210A, FOSL2, GEM, GZF1, HIC1, MAFG, PDCD1, RANBP2, RIN3, SDF2, SLAMF7, ZFYVE16
Most correlated modules
- TNF/NF-kB response · correlation 0.86
- Atypical memory B cell · correlation 0.79
- NF-kB activation/survival · correlation 0.76
- B-cell activation · correlation 0.75
- BCR Signaling Regulation · correlation 0.73
- NF-kB signaling · correlation 0.73
- Activated B cell · correlation 0.71
- Immediate early response · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.