PRDX6 — Peroxiredoxin 6
PRDX6 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PRDX6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin Remodeling DNA/chromatin regulation | ANP32B, ATP5IF1, CALM3, CBX3, COMMD4, HAT1, HMGA1, HMGB1 +9 more | View in SCUBA |
| CD8⁺ T cells | RNA Splicing Complex RNA processing & translation | ATP6V0B, ATP6V1F, EIF3I, MRPS6, NDUFS7, PARK7, PSMD4, SF3B5 +3 more | View in SCUBA |
| Endothelial | Inflammatory Endothelial Activation Inflammation | ANXA6, CNIH1, COTL1, DEGS1, DHRS7, F2R, FKBP10, FSTL1 +8 more | View in SCUBA |
| Gamma-delta T cells | AHR/NF-κB Survival Immune regulation | ABCC1, AHR, ANKRD37, AREG, BAIAP2, BCL2L11, BEND4, BIRC3 +24 more | |
| Smooth muscle cells | Ribonucleoprotein & translation RNA processing & translation | CRYAB, CYB5R3, EEF1B2, HMGB1, HNRNPC, LAPTM4A, MAGED2, NACA +5 more | View in SCUBA |
About the gene
| Synonyms | 1-Cys, aiPLA2, AOP2, KIAA0106, MGC46173, NSGPx, p29, PRX |
|---|---|
| Chromosome | 1: 173477330-173488815 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Antioxidant, Hydrolase, Multifunctional enzyme, Oxidoreductase, Peroxidase, Transferase |
| Biological process | Lipid degradation, Lipid metabolism |
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis. Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3- phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero- 3-phosphocholine or PC). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.