USP1 — Ubiquitin specific peptidase 1
USP1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
USP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Replication Licensing Cell cycle | ASF1B, CDC6, CDCA5, CDT1, CENPK, CENPU, CLSPN, DNAJC9 +5 more | View in SCUBA |
| Endothelial | DNA Damage Repair DNA/chromatin regulation | APPL1, GPAA1, HMGB1, HNRNPM, HNRNPR, NAP1L4, NCL, PRDX3 +7 more | View in SCUBA |
| Macrophages | Centrosome & DNA Repair Cell cycle | ANKRD13A, BRCA2, CASP2, CBX5, CCDC14, CEP152, CEP78, CKAP5 +34 more | View in SCUBA |
About the gene
| Chromosome | 1: 62436297-62451804 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protease, Thiol protease |
| Biological process | DNA damage, DNA repair, Ubl conjugation pathway |
Function
Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.