Immediate early response
Gene co-expression module in CD19⁺ B cells
| Category | Stress |
|---|---|
| Genes | 18 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes TOB1, GADD45A, GADD45B, CITED2, SERTAD1, IER5L, ZC3H12A, CEBPB are classic immediate-early / stress-response and growth-arrest genes. TOB1 is an anti-proliferative BTG/TOB family member, GADD45A/B are growth arrest/DNA damage inducible, PLK2 and HEXIM1 are stress-induced, ZC3H12A (Regnase-1) and CEBPB are inflammatory/IEG regulators. This pattern of immediate-early genes co-expressed in a core module is the signature of a dissociation/cell-separation stress program rather than true in vivo activation, though it correlates with CD inflammation. The presence of TCF7 and HSPA2 is peripheral. The constellation of IEGs strongly suggests transcriptional stress response.
Genes
ABHD5, CEBPB, CITED2, FAM53C, GADD45A, GADD45B, HEXIM1, HSPA2, IER5L, INTS6, IQCN, MYLIP, PLK2, PPP1R10, SERTAD1, TCF7, TOB1, ZC3H12A
Most correlated modules
- ATF4 Stress Response · correlation 0.81
- Integrated Stress Response · correlation 0.78
- Immediate Early NFkB · correlation 0.73
- AP-1 Immediate Early · correlation 0.72
- Early Response Stress · correlation 0.71
- mRNA Splicing · correlation 0.69
- Heat Shock Response · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.