Activated Effector ISG
Gene co-expression module in CD4⁺ T cells
| Category | Anti-viral |
|---|---|
| Genes | 17 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 17 genes have a known function matching the annotation |
Why this annotation
Mixed module with interferon-stimulated genes (RSAD2), chemokine XCL1, SLAMF8, NMUR1, KIT, RELT (TNFR family). XCL1 and RSAD2 suggest activated/effector T cell state with anti-viral component. SLAMF8 and RELT immune activation. Low expression, lowly detected, no clear single program. Leans toward an innate-like activated/anti-viral effector signature.
Genes
GOLGA7B, KIF5C, KIT, MAP2K6, MVB12B, NMUR1, PLCG1, PLOD3, POC1B, PRKAB1, RELT, RSAD2, SLAMF8, TMCC3, TMEM200A, TRIM41, XCL1
Most correlated modules
- Mixed Metabolic Ambient · correlation 0.95
- Glycosylation & trafficking · correlation 0.93
- PD-L1 checkpoint · correlation 0.86
- Oxidative phosphorylation · correlation 0.78
- Respiratory chain assembly · correlation 0.78
- Chromatin Regulation · correlation 0.69
- Vesicular trafficking · correlation 0.69
- mRNA Splicing Factors · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.