KIT — KIT proto-oncogene, receptor tyrosine kinase
KIT belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KIT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated Effector ISG Anti-viral | GOLGA7B, KIF5C, MAP2K6, MVB12B, NMUR1, PLCG1, PLOD3, POC1B +8 more | View in SCUBA |
| Endothelial | CXCL12 Angiogenic Chemotaxis Chemotaxis | ACKR3, AFAP1L1, ARHGAP18, ARHGEF7, CHST1, CXCR4, FHL3, FSCN1 +15 more | View in SCUBA |
| Hematopoietic progenitor cells | Hematopoietic Progenitor Identity Stemness | CD38, DAD1, HSH2D, HYAL3, ITGAE, MBOAT2, MTHFD2, PARVB +2 more | |
| Innate lymphoid cells | ILC Identity Program Differentiation | AHR, APOL4, ARHGEF12, BLVRA, CD300LF, CDK2AP2, CEP83, COL4A4 +29 more | View in SCUBA |
About the gene
| Synonyms | C-Kit, CD117, PBT, SCFR |
|---|---|
| Chromosome | 4: 54657267-54740783 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins |
| Molecular function | Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Function
Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.