MVB12B — Multivesicular body subunit 12B
MVB12B belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MVB12B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated Effector ISG Anti-viral | GOLGA7B, KIF5C, KIT, MAP2K6, NMUR1, PLCG1, PLOD3, POC1B +8 more | View in SCUBA |
| Gamma-delta T cells | cAMP Lipid Signaling Immune regulation | ABL1, AKIRIN2, B9D2, CEMIP2, CHPT1, CTDP1, DKK3, GGA2 +15 more | |
| Macrophages | Macrophage Migration Migration & adhesion | CEMIP2, CPM, EPB41L2, EPS8, GBE1, ITGA9, KCNQ1, MAN1A1 +12 more | View in SCUBA |
| Mucosal-associated invariant T cell | TCR Signal Attenuation Immune regulation | AFF4, BORCS5, CENPC, CHD2, CRACR2A, CRYBG1, DUSP16, FAS +8 more |
About the gene
| Synonyms | C9orf28, FAM125B, FLJ00001 |
|---|---|
| Chromosome | 9: 126326829-126507041 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Protein transport, Transport |
Function
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.