JAK-STAT Signaling
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 16 genes have a known function matching the annotation |
Why this annotation
Neighbor of the IFN module M93. Contains JAK3 and STAT5B (cytokine/JAK-STAT signaling), SAMD9L (interferon-induced), GSDMD (inflammasome/pyroptosis effector), and several RNA-binding/regulatory genes (DDX17, MBNL1, CELF2, SETX). The mix of JAK-STAT signaling, IFN-inducible genes, and inflammatory effectors, plus its inflammation-up/treatment-down disease pattern, supports an immune signaling/cytokine response program co-expressed with the IFN neighborhood. Moderate coherence reflects mixed RNA-processing members.
Genes
ARHGAP30, CELF2, DDX17, DNAJC1, GSDMD, HCLS1, JAK3, MBNL1, N4BP2L2, NSD1, OGT, SAMD9L, SETX, STAT5B, TGOLN2, UBXN4
Most correlated modules
- Immune Regulation · correlation 0.85
- Interferon response · correlation 0.84
- Interferon Response · correlation 0.84
- T Cell Signaling · correlation 0.83
- TCR Activation Signaling · correlation 0.81
- OxPhos & proteasome · correlation 0.79
- Lipid Metabolism · correlation 0.78
- Leukocyte Motility · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.