Th17/MAIT type-17
Gene co-expression module in CD4⁺ T cells
| Category | Th17 fate |
|---|---|
| Genes | 18 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 18 genes have a known function matching the annotation |
Why this annotation
This module is dominated by MAIT/Th17-associated markers: SLC4A10 is a canonical MAIT cell marker, IL22 and CCL20 are Th17/MAIT effector cytokines, IL4I1 is an AHR-pathway enzyme highly expressed in MAIT/Th17, CEBPD and CA2/CA10 accompany the type 17 program. LRRN3 marks MAIT/innate-like T cells. The strong coherence and presence of SLC4A10 + IL22 + IL4I1 + CCL20 strongly indicate a Th17/MAIT type-17 effector module.
Genes
AKT1S1, CA10, CA2, CCL20, CEBPD, GFPT2, IL22, IL4I1, LRRN3, LZTS1, NEO1, PELO, RAB6B, RGS18, SLC4A10, SPRY1, TLE1, TRIQK
Most correlated modules
- Cytokine signaling · correlation 0.84
- Gamma-delta T cell · correlation 0.78
- T cell co-receptors · correlation 0.73
- Cytokine receptor signaling · correlation 0.69
- Cytotoxic Effector CD4 · correlation 0.63
- Effector activation NFkB · correlation 0.58
- Resting memory T cell · correlation 0.57
- NF-kB Feedback Response · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.