Cytotoxic Effector CD4
Gene co-expression module in CD4⁺ T cells
| Category | Cytotoxicity |
|---|---|
| Genes | 22 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes mix cytotoxic/effector (CCL5, TRGC2, MATK, DPP4, HOPX, TNFSF9) with adhesion (ITGA1) and interferon-induced (IFIT2, PARP8). ITGA1, CCL5, DPP4(CD26), HOPX and MATK are markers of tissue-resident effector/cytotoxic CD4 T cells. The signature reflects an effector/cytotoxic CD4 tissue-resident program. CCL5, MATK, TNFSF9, IFIT2 support effector cytotoxic state. Decreased with UC inflammation. Best fits cytotoxic/effector program.
Genes
ADAM8, ADRB2, CCL5, CHD9, DPP4, HIC1, HOPX, IFIT2, ITGA1, LYSMD2, MATK, MID1IP1, NEU1, PARP8, PNP, PTGER2, RASSF1, SLC20A1, SLF1, TMEM107, TNFSF9, TRGC2
Most correlated modules
- T cell co-receptors · correlation 0.78
- Cytokine signaling · correlation 0.73
- mRNA Splicing Factors · correlation 0.70
- Resting memory T cell · correlation 0.67
- Transcriptional regulation · correlation 0.66
- Th17/MAIT type-17 · correlation 0.63
- Activated Effector ISG · correlation 0.63
- Cytotoxic effector · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.