Cytokine signaling
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 21 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 21 genes have a known function matching the annotation |
Why this annotation
Hub TNFSF13B (BAFF) plus IFNGR1, GPR65, ABCB1, ERN1, and IFI44. GPR65 is an IBD risk gene (pH sensor in T cells); TNFSF13B/BAFF is involved in B cell help; IFNGR1 is interferon-gamma receptor. ERN1 is UPR. The mixture of cytokine signaling and a B-cell-helping ligand (BAFF) with IFNGR1 leans toward an immune signaling/helper program. The presence of TNFSF13B and IFNGR1 suggests an immune effector/regulatory signaling module. Moderate specificity; labeling as cytokine signaling/immune regulation.
Genes
ABCB1, ARHGEF40, AUTS2, COLQ, DSE, ERN1, GPR65, IFI44, IFNGR1, LTK, ME1, MYBL1, PLCB1, PPP3CA, PRSS35, SPON1, TNFSF13B, TPBG, TPD52, TSPAN15, ZNF652
Most correlated modules
- Th17/MAIT type-17 · correlation 0.84
- Resting memory T cell · correlation 0.84
- Cytotoxic Effector CD4 · correlation 0.73
- Gamma-delta T cell · correlation 0.70
- T cell co-receptors · correlation 0.69
- Cytotoxic effector · correlation 0.69
- Cytokine receptor signaling · correlation 0.68
- TCR signaling · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.